Publications: 2016 to 2021

J. Bierlmeier, M. Alvaro-Benito, M. Scheffler, K. Sturm, L. Rehkopf, C. Freund, D. Schwarzer
Angew Chem Int Ed 2021 Nov 4. doi: 10.1002/anie.202109032. Online ahead of print. PMID: 34735044  
Link to the article

P. Wolf, A. Mohr, G. Gavins, V. Behr, K. Mörl, O. Seitz, A.G. Beck-Sickinger
ChemBioChem2021, accepted
Orthogonal peptide-templated labeling elucidates lateral ETAR/ETBR proximity and reveals altered downstream signalling
Link to the article

P. Werther+, K. Yserentant+, F. Braun, K. Grussmayer, V. Navikas, M. Yu, Z. Zhang, M.J. Ziegler, C. Mayer, A.J. Gralak, M. Busch, W. Chi, F. Rominger, A. Radenovic, X. Liu, E.A. Lemke, T. Buckup, D.-P. Herten*, R. Wombacher*
ACS Cent. Sci. 2021, 7(9), 1561–157
Bioorthogonal red and far-red fluorogenic probes for wash-free live-cell and super-resolution microscopy
Link to the article

G.C. Gavins, K. Gröger, M. Reimann, M.D. Bartoschek, S. Bultmann, O. Seitz
RSC Chem. Biol.2021,2(4), 1291-1295
Orthogonal coiled coils enable rapid covalent labelilng of two distinct membrane proteins with peptide nucleic acid barcodes
Link to the article

T. F. Fischer, A.S. Czerniak, T. Weiß, C.T. Schoeder, P. Wolf, O. Seitz O, J. Meiler, A.G. Beck-Sickinger
Cell Mol Life Sci. 2021, 78(17-18), 6265-6281
Ligand-binding and -scavenging of the chemerin receptor GPR1
Link to the article

A.F.L. Schneider, L. Benz, M. Lehmann, C.P.R. Hackenberger
Angew. Chem. Int. Ed. 2021, 60(40), 22075-22080
Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution
Link to the article
Angew. Chem.2021, 133(40), 22246-22252
Zellpermeable Nanobodys ermöglichen Zwei-Farben-Superauflösungsmikroskopie in lebenden, nicht transfizierten Zellen
Link to the article

C.E. Stieger, L. Franz, F. Körlin, C.P.R. Hackenberger
Angew. Chem. Int. Ed. 2021, 60(28), 15359-15364
Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging
Link to the article
Angew. Chem. 2021, 133(28), 15487-15492
Diethinylphosphinate für die Cystein-selektive Proteinmarkierung und Disulfid-Verbrückung
Link to the article

A.F.L. Schneider, M. Kithil, M.C. Cardoso, M. Lehmann, C.P.R. Hackenberger
Nature Chemistry 2021, 13, 530-539
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
Link to the article

E. Höllmüller, S. Geigges, M. Niedermeier, K.-M. Kammer, S. Kienle, D. Rösner, M. Scheffner, A. Marx, F. Stengel
Nat. Comm. 2021, 12, 3497
Site-specific ubiquitylation acts as a regulator of linker histone H1”
Link to the article

M. Boschanski, T. Krüger, L. Karsten, G. Falck, S. Alam, M. Gerlach, B. Muller, K.M. Müller, N. Sewald, T. Dierks
Bioconjugate Chemistry2021, 32, 1167–1174
Site-Specific Conjugation Strategy for Dual Antibody-Drug Conjugates Using Aerobic Formylglycine-Generating Enzymes
Link to the article

P. Wolf, A.G. Beck-Sickinger
J. Pept Sci.2021, 27(7), e3325
The ring size of monocyclic ET-1 controls selectivity and signaling efficiency at both endothelin receptor subtypes
Link to the article

Y. Park*, A.L. Baumann*, H. Moon, S. Byrne, M.-A. Kasper, S. Hwang, H. Sun, M.-H. Baik, C.P.R. Hackenberger
Chem. Sci. 2021, 12, 8141-8148
The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols
Link to the article

C.D. Reinkemeier, C. Koehler, P.F. Sauter, N.V. Shymanska, C. Echalier, A. Rutkowska, D.W. Will, C. Schultz, E.A. Lemke
Chemistry2021, 27(19), 6094-6099
Synthesis and Evaluation of Novel Ring-Strained Noncanonical Amino Acids for Residue-Specific Bioorthogonal Reactions in Living Cells
Link to the article

J.E.G.A. Dold, V. Wittmann
ChemBioChem2021, 22, 1243-1251
Metabolic Glycoengineering with Azide- and Alkene-Modified Hexosamines: Quantification of Sialic Acid Levels
Link to the article

L.M. Haiber, M. Kufleitner, V. Wittmann
Front. Chem. 2021, 9, 654932
Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering
Link to the article

J. Schwach, K. Kolobynina, K. Brandstetter, M. Gerlach, P. Ochtrop, J. Helma, C.P.R. Hackenberger. H. Harz, M.C. Cardoso, H. Leonhardt, A. Stengl
ChemBioChem 2021, 22(7), 1205-1209
Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
Link to the article

C. Freund, D. Schwarzer
Chembiochem2021, 22, 1347-1356
Engineered Sortases in Peptide and Protein Chemistry
Link to the article

S.L. Scinto, D.A. Bilodeau, R. Hincapie, W. Lee, S.S. Nguyen, M. Xu, C.W. am Ende, MG Finn, K. Lang, Q. Lin, J.P. Pezacki, J.A. Prescher, M.S. Robillard, J.M. Fox*
Nat Rev Methods Primers2021, 1,30
Bioorthogonal chemistry
Link to the article

M.D. Bartoschek, E. Ugur, T.A. Nguyen, G. Rodschinka, M. Wierer, K. Lang*, S. Bultmann*
Nucleic Acids Research2021, gkab132
Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells
Link to the article

M.F. Sánchez, S. Els-Heindl, A.G. Beck-Sickinger, R. Wieneke, R. Tampé
Science2021, 371, abb7657
Photo-induced receptor confinement drives ligand-independent GPCR signaling
Link to the article

J. Brunnberg, V. Herbring, E. Günther Castillo, H. Krüger, R. Wieneke, R. Tampé
Commun Biol2021, 4, 430
Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
Link to the article

S. Palei, H.D. Mootz
Chem. Comm.2021, 57, 4194-4197
Semisynthetic head-to-tail cyclized peptides obtained by combining protein trans-splicing and intramolecular expressed protein ligation
Link to the article

P. Wolf, G. Gavins, A.G. Beck-Sickinger, O. Seitz
Chembiochem 2021, 22(10), 1717-1732
Strategies for Site-Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags
Link to the article

G.C. Gavins, K. Gröger, M.D. Bartoschek, P. Wolf , A.G. Beck-Sickinger, S. Bultmann, O. Seitz
Nat Chem. 2021, 13(1), 15-23
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins
Link to the article

S. Hoffmann, M.E. Terhorst, R.K. Singh, D. Kümmel, S. Pietrokovski*, H.D. Mootz*
ChemBioChem 2021, 22, 364-373
Biochemical and structural characterization of an unusual and naturally split class 3 intein
Link to the article

A. Yang, S. Pantoom, Y.W. Wu
ChemBioChem 2020, 21(23), 3377-3382
Distinct Mechanisms for Processing Autophagy Protein LC3-PE by RavZ and ATG4B
Link to the article

P. Ochtrop, C.P.R. Hackenberger
Curr. Op. in Chem. Biology 2020, 58, 28-36
Recent advances of thiol-selective bioconjugation reactions (review)
Link to the article

M. Bhagawati, S. Hoffmann, K.S. Höffgen, J. Piehler, K.B. Busch, H.D. Mootz
Angew. Chem. Int. Ed. 2020, 59, 21007-21015
In cellulo protein semi-synthesis from endogenous and exogenous fragments using the ultra-fast split Gp41-1 intein
Link to the article

N. Janson, T. Krüger, L. Karsten, M. Boschanski, T. Dierks, K.M. Müller, N. Sewald
ChemBioChem2020, 21(24), 3580-3593
Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs
Link to the article

D. Aparicio Pelaz, Z. Yerkesh, S. Kirchgäßner, H. Mahler, V. Kharchenko, D. Azhibek, M. Jaremko, H.D. Mootz, Ł. Jaremko, D. Schwarzer, W. Fischle
Chem. Sci. 2020, 11, 9218-9225
Examining histone modification crosstalk using immobilized libraries established from ligation-ready nucleosomes
Link to the article

C. Koehler, G. Estrada Girona, C.D. Reinkemeier, E.A. Lemke
Chembiochem2020, 21(22), 3216-3219
Inducible Genetic Code Expansion in Eukaryotes
Link to the article

M. Baalmann, L. Neises, S. Bitsch, H. Schneider, L. Deweid, P. Werther, N. Ilkenhans, M. Wolfring, M.J. Ziegler, J.A. Wilhelm, H. Kolmar, R. Wombacher
Angew. Chem. Int. Ed.2020, 59(31), 12885-12893
Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates.
Link to the article

S. Ernst, F. Ecker, M.S. Kaspers, P. Ochtrop, C. Hedberg, M. Groll, A. Itzen
Sci. Adv. 2020, 6, eaaz8041
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
Link to the article

M.J. Ziegler, R. Wombacher
Methods Enzymol.2020, 638, 259-271
Light-induced protein proximity by activation of gibberellic acid derivatives in livving cells.
Link to the article

A.L. Baumann, S. Schwagerus, K. Broi, K. Kemnitz-Hassanin, C.E. Stieger, N. Trieloff, P. Schmieder, C.P.R. Hackenberger
JACS 2020, 142(20), 9544-9552
Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations
Link to the article
highlighted in: Synfacts 2020, 16(07), 0851, DOI: 10.1055/s-0040-1707878
Link to the article

C. Gallrein, M. Iburg, T. Michelberger, A. Kocak, D. Puchkov, F. Liu, S.M. Ayala Mariscal, T. Nayak, G.S. Kaminski Schierle, J. Kirstein
Progress in Neurobiology 2020, 198, 101907
Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
Link to the article

M. Iburg, D. Puchkov, I.U.R. Brugada, L. Bergemann, U. Rieprecht, J. Kirstein
J Biol Chem2020, 295(10), 3064-3079
The non-canonical small heat shock protein HSP-17 from C. elegans is a selective protein aggregase
Link to the article

M.-A. Kasper, M. Gerlach, A.F.L. Schneider, C. Groneberg, P. Ochtrop, S. Boldt, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C.P.R. Hackenberger
ChemBioChem 2020, 21, 113-119
N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
Link to the article

P. Werther, K. Yserentant, F. Braun, N. Kaltwasser, C. Popp, M. Baalmann, D.P. Herten, R. Wombacher
Angew. Chem. Int. Ed. 2020, 59, 804-810
Live-Cell Localization Microscopy with a Fluorogenic and Self-Blinking Tetrazine Probe.
Link to the article

D. Ollech, T. Pflästerer, A. Shellard, C. Zambarda, J.P. Spatz, P. Marcq, R. Mayor, R. Wombacher, E.A. Cavalcanti-Adam
Nat. Comm.2020, 11, 1-13
An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells.
Link to the article

M.J. Schöwe, O. Keiper, C. Unverzagt, V. Wittmann
Chem. Eur. J. 2019, 25, 15759-15764
A Tripeptide Approach to the Solid-Phase Synthesis of Peptide Thioacids and N-Glycopeptides
Link to the article

A.L. Baumann, C.P.R. Hackenberger
Curr. Opin. Chem. Biol. 2019, 52, 39-46
Tag and release: strategies for the intracellular cleavage of protein conjugates (Review)
Link to the article

M. Bhagawati, T.M.E. Terhorst, F. Füsser, S. Hoffmann, T. Pasch, S. Pietrokovski*, H.D. Mootz*
Proc. Natl. Acad. Sci. USA2019, 116, 22164-22172
A mesophilic cysteine-less split intein for protein trans-splicing applications under oxidizing conditions
Link to the article

S.V. Mayer1, A. Murnauer1, M.K. von Wrisberg, M.L. Jokisch, K. Lang*
Angew. Chem. Int Ed.2019, 58, 15876-15882
Photo-Induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes
Link to the article

P. Ochtrop, S. Ernst, A. Itzen, C. Hedberg
ChemBioChem2019, 20(18), 2336-2340
Exploring the substrate scope of the phosphocholine transferase AnkX for versatile protein functionalisation
Link to the article

M.-A. Kasper, A. Stengl, P. Ochtrop, M. Gerlach, T. Stoschek, D. Schumacher, J. Helma, M. Penkert, E. Krause, H. Leonhardt, C.P.R. HackenbergerAngew. Chem. Int. Ed. 2019, 58(34), 11631-11636
Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates
Link to the article
Angew. Chem. 2019, 131(34), 11757-11762
Link to the article

M.-A. Kasper, M. Glanz, A. Stengl, M. Penkert, S. Klenk, T. Sauer, D. Schumacher, J. Helma, E. Krause, C. Cardoso, H. Leonhardt, C.P.R. Hackenberger
Angew. Chem. Int. Ed. 2019, 58(34), 11625-11630
Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations
Link to the article
Angew. Chem. 2019, 131(34), 11751-11756
Cysteinselektive phosphonamidatbasierte Elektrophile für modulare Biokonjugationen
Link to the article

S. Hofmann, D. Januliene, A.R. Mehdipour, C. Thomas, E. Stefan, S. Brüchert, B.T. Kuhn, E.R. Geertsma, G. Hummer, R. Tampé
Nature 2019, 471, 580-583
Conformation space of a heterodimeric ABC exporter under turnover conditions
Link to the article

K. Lang*
Biochemistry2019, 58, 2703-2705 (invited news and view)
Installing Terminal-Alkyne Reactivity into Proteins in Engineered Bacteria
Link to the article

M. Gerlach, T. Stoschek, H. Leonhardt, C.P.R. Hackenberger, D. Schumacher, J. Helma
Methods Mol Biol. 2019, 2012, 327-355
Tubulin Tyrosine Ligase-Mediated Modification of Proteins
Link to the article

M. Giess, A. Munoz-Lopez, B. Buchmuller, G. Kubik and D. Summerer*
J. Am. Chem. Soc. 2019, 141, 9453-7
Programmable Protein-DNA Crosslinking for the Direct Capture and Quantification of 5-Formylcytosine
Link to the article

T. Krüger, S. Weiland, M. Boschanski, P.K. Sinha, G. Falck, K.M. Müller, T. Dierks, N. Sewald
ChemBioChem2019,20(16: Special Issue: 10th IPS), 2074-2078
Conversion of Serine-Type Aldehyde Tags by the Radical SAM Protein AtsB from Methanosarcina mazei
Link to the article

M.-A. Kasper, M. Glanz, A. Oder, P. Schmieder, J.P. von Kries, C.P.R. Hackenberger
Chem Sci. 2019, 10, 6322-6329
Vinylphosphonites for Staudinger-induced chemoselective peptide cyclizaton and functionalization
Link to the article

J.S. Möhler, P. Werther, R. Wombacher
Proximity-Induced Bioorthogonal Chemistry Using Inverse Electron Demand Diels-Alder Reaction. In Proximity Labeling; Humana, New York, NY, 2019, 147-163
Link to the article

A. Stengl, M. Gerlach, M.-A. Kasper, C.P.R. Hackenberger, H. Leonhardt, D. Schumacher, J. Helma
OBC 2019, 17, 4964-4969
TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles
Link to the article

M. Baalmann, M.J. Ziegler, P. Werther, J. Wilhelm, R. Wombacher
Bioconjugate Chemistry 2019, 30, 1405-1414
Enzymatic and Site-Specific Ligation of Minimal-Size Tetrazines and Triazines to Proteins for Bioconjugation and Live-Cell Imaging
Link to the article

C.D. Reinkemeier, G. Estrada Girona, E.A. Lemke
Science2019, 363, No. 6434
Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes
Link to the article

M. Reille-Seroussi, S.V. Mayer, W. Dörner, K. Lang and H.D.D. Mootz*
Chem. Comm.2019, 55, 4793-4796
Expanding the Genetic Code with a Lysine Derivative Bearing an Enzymatically Removable Phenylacetyl Group
Link to the article

T. Krüger, T. Dierks, N. Sewald
BIOLOGICAL CHEMISTRY2019, 400(3),289-297
Formylglycine-generating enzymes for site-specific bioconjugation
Link to the article

M. Effenberger, A. Stengl, K. Schober, M. Gerget, M. Kampick, T.R. Müller, D. Schumacher, J. Helma, H. Leonhardt, D.H. Busch
J Immunol. 2019,202, 2164-2171
FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers
Link to the article

M. Fottner, A-D. Brunner, V. Bittl, D. Horn-Ghetko, A. Jussupow, V.R.I. Kaila, A. Bremm and K. Lang*
Nat Chem Biology2019, 15, 276-284
Site-specific ubiquitylation and SUMOylation using genetic code expansion and sortase
Link to the article

B. Di Ventura, H.D. Mootz
Biol. Chem., 2019, 400, 467-475
Switchable inteins for conditional protein splicing
Link to the article

A.F.L. Schneider, A.L.D. Wallabregue, L. Franz, C.P.R. Hackenberger
Bioconjugate Chem. 2019, 30(2), 400-404
Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides
Link to the article

D.R. Feleciano, K. Juenemann, M. Iburg, I. Bras, C.I. Holmberg, J. Kirstein
Frontiers in Aging Neuroscience 2019, Jan 29;11:9
Crosstalk between chaperone-mediated protein disaggregation and proteolytic pathways in aging and disease
Link to the article

S. Palei, K.-S. Becher, C. Nienberg, J. Jose, H.D. Mootz
ChemBioChem 2019, 20, 72-77
Bacterial cell surface display of semisynthetic cyclic peptides
Link to the article

V. F. Schart, J. Hassenrück, A.-K. Späte, J. E. G. A. Dold, R. Fahrner, V. Wittmann
ChemBioChem2019, 20, 166-171
Triple Orthogonal Labeling of Glycans Applying Photoclick Chemistry
Link to the article

M. Braner, N. Koller, J. Knauer, V. Herbring, S. Hank, R. Wieneke, R. Tampé
Chem. Sci 2018, 10, 2001-2005
Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors
Link to the article

A. Baumann, C.P.R. Hackenberger
CHIMIA 2018, 72(11), 802-808
Modern Ligations Methods to Access Natural and Modified Proteins
Link to the article

H.Y. Chiu, J.A. Bates, J. Helma, H. Engelke, H. Harz, T. Bein, H. Leonhardt*
Nucleus 2018, 9, 530-542
Nanoparticle Mediated Delivery and Small Molecule Triggered Activation of Proteins in the Nucleus
Link to the article

J.C.J. Matern, K. Friedel, J. Binschik, K.-S. Becher, Z. Yilmaz, H.D. Mootz
J. Am. Chem. Soc.2018, 140, 11267-11275
Altered coordination of individual catalytic steps in different and evolved inteins reveals kinetic plasticity of the protein splicing pathway
Link to the article

T.A. Nguyen, M. Cigler, K. Lang*
Angew. Chem. Int. Ed.2018, 57, 14350-14361
Expanding the Genetic Code to Study Protein–Protein Interactions
Link to the article

A. Klein, S. Hank, A. Raulf, E.F. Joest, F. Tissen, M. Heilemann, R. Wieneke, R. Tampé
Chem Science, 2018, 9, 7835
Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies
Link to the article

H. Neumann*, P. Neumann-Staubitz, A. Witte and D. Summerer*
Curr. Opin. Chem. Biol.2018, 45, 1-9
Epigenetic chromatin modification by amber suppression technology
Link to the article

A. Zemella, L. Thoring, C. Hoffmeister, M. Samalikova, P. Ehren. D.A. Wüstenhagen, S. Kubick
Scientific Reports 2018, 8, Art. no. 8514
Cell-free protein synthesis as a novel tool for directed glycoengineering of active erythropoietin
Link to the article

T. Pirzer, K.S. Becher, M. Rieker, T. Meckel, H.D. Mootz, H. Kolmar
ACS Chem. Biol.2018, 13, 2058-2066
Generation of potent anti-HER1/2 immunotoxins by protein ligation using split inteins
Link to the article

A. Kormos, C. Koehler, E.A. Fodor, Z.R. Rutkai, M.E. Martin, G. Mező, E.A. Lemke, P. Kele
Chemistry 2018, 24(35), 8841-8847
Bistetrazine-Cyanines as Double-Clicking Fluorogenic Two-Point Binder or Crosslinker Probes
Link to the article

P. Rathi, S. Maurer, D. Summerer
Philos. Trans. r. Soc. Lond. B Biol. Sci. 2018, 373, 1748
Selective Recognition of N4-Methylcytosine in DNA by Engineered Transcription-Activator-Like Effectors
Link to the article

T Krüger, S. Weiland, G. Falck, M. Gerlach, M. Boschanski, S. Alam, K.M. Müller, T. Dierks, N. Sewald
Angewandte Chem. Int. Ed. 2018, 57(24), 7245-7249
Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes.
Link to the article

D. Schumacher, J. Helma, A.F.L. Schneider, H. Leonhardt, C.P.R. Hackenberger
Angewandte Chem. 2018, 130, 2336-2357
Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen.
Angewandte Chem. Int. Ed.2018, 57(9), 2314-2333.
Chemical functionalization strategies and intracellular applications of nanobodies.
Link to the article

J. Helma, H. Leonhardt, C.P.R. Hackenberger, D. Schumacher
Methods Mol Biol.2018, 1728, 67-93
Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids
Link to the article

M. Baalmann, M. Best, R. Wombacher
Site-specific protein labeling utilizing lipoic acid ligase (LplA) and bioorthogonal inverse electron demand diels-alder reaction.
in: Noncanonical Amino Acids;Humana Press, New York, NY, 2018, 365-387
Link to the article

M.J. Schmidt, D. Summerer
Directed Evolution of Orthogonal Pyrrolysyl-tRNA Synthetases in Escherichia coli for the Genetic Encoding of Noncanonical Amino Acids. In: Lemke E. (eds) Noncanonical Amino Acids. Methods in Molecular Biology, 2018, vol 1728. Humana Press, New York, NY
Link to the article

A. Muñoz-López Á, D. Summerer*
Chem Rec. 2018, 18(1), 105-116
Recognition of Oxidized 5-Methylcytosine Derivatives in DNA by Natural and Engineered Protein Scaffolds
Link to the article

G. Falck, K.M. Müller
Antibodies2018, 7(1), 4
Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics
Link to the article

K. Lang*
ChemBioChem 2018, 19, 115-120 (Conference Report)
Building Peptide Bonds in Haifa: The Seventh Chemical Protein Synthesis (CPS) Meeting
Link to the article

J. Lotze, U. Reinhardt, O. Seitz, K. Mörl,A.G. Beck-Sickinger
ACS Chem Biol. 2018, 13(3), 618-627.
Time-Resolved Tracking of separately Internalized Neuropeptide Y(2) Receptors by Two-Color Pulse-Chase.
Link to the article

A. Scior, K. Arnsburg, M. Iburg, K. Juenemann, M.L. Pigazzini, B. Mlody, D. Puchkov, A. Ast, A. Buntru, J. Priller, E.E. Wanker, A. Prigione, J. Kirstein
The EMBO Journal 2018, 37, 282-299.
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a chaperone complex.
Link to the article

S. Middel, C.H. Panse, S. Nawratil, U. Diederichsen
Chem. Bio. Chem. 2017, 18(23), 2328-2332
Native Chemical Ligation Directed by Photocleavable Peptide Nucleic Acid (PNA) Templates
Link to the article

A.F.L. Schneider, C.P.R. Hackenberger
Curr. Opin. in Biotechnology 2017, 48, 61-68
Flourescent labeling in living cells.
Link to the article

J. Kirstein, K. Arnsburg, A. Scior, A. Szlachcic, D.L. Guilbride, R. I. Morimoto, B. Bukau, N. B. Nillegoda
Aging Cell 2017, 16(6), 1414-1424
In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging
Link to the article

P. Werther, J.S. Möhler, R. Wombacher
Chem. Eur. J. 2017, 72, 18216-18224
A Bifunctional Fluorogenic Rhodamine Probe for Proximity-Induced Bioorthogonal Chemistry.
Link to the article

M. Cigler, T.G. Müller, D. Horn-Ghetko, M.-K. von Wrisberg, M. Fottner, R.S. Goody, A. Itzen, M.P.  Müller, K. Lang
Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201706927
Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes in vitro and in vivo.
Link to the article

K. Gröger, G. Gavins, O. Seitz
Angew. Chem. Int. Ed.2017, 56, 14217-14221
Strand Displacement in Coiled-Coil Structures - Controlled Induction and Reversal of Proximity
Link to the article

A. Blees, D. Januliene, T. Hofmann, N. Koller, C. Schmidt, S. Trowitzsch, A. Moeller, R. Tampé
Nature 2017, 551, 525-528
Structure of the human MHC-I peptide-loading complex
Link to the article

P. Rathi, A. Witte, D. Summerer
Sci. Rep. 2017, 7(1), 15067
Engineering DNA Backbone Interactions Results in TALE Scaffolds with Enhanced 5-Methylcytosine Selectivity.
Link to the article

L. Schmohl, J. Bierlmeier, N. von Kügelgen, L. Kurz, P. Reis, F. Barthels, P. Mach, M. Schutkowski, C. Freund, D. Schwarzer
Bioorg Med. Chem. 2017, 25, 5002-5007
Identification of sortase substrates by specificity profiling
Link to the article

A. Yang, I. Hacheney, Y.W. Wu
Bioorg & Med Chemistry 2017, 25(18), 4971-4976
Semisynthesis of qutophagy protein LC3 conjugates.
Link to the article

H.D. Herce, D. Schumacher, A.F.L. Schneider, A.K. Ludwig, F.A. Mann, M. Filies, M.-A. Kasper, S. Reinke, E. Krause, H. Leonhardt, M.C. Cardoso, C.P.R. Hackenberger
Nature Chemistry 2017, 9, 762-771
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.
Link to the article

Link to supplementary movie

S. Pantoom, A. Yang, Y.W. Wu
Autophagy 2017, 13(8), 1467-1469
Lift and cut: Anti-host autophagy mechanism of Legionella pneumophila.
Link to the article

A.-L. Bachmann, H.D. Mootz
J. Pep. Sci 2017, in press, DOI: 10.1002/psc.2996
N-terminal chemical protein labeling using the naturally split GOS-TerL intein.
Link to the article

A. Zemella, S. Grossmann, R. Sachse, A. Sonnabend, M. Schaefer, S. Kubick
Scientific Reports 2017, 7:3740, DOI: 10.1038/s41598-017-03955-8
Qualifying a eukaryotic cell-free system for fluorescence based GPCR analyses
Link to the article

E. Kozma, G. Estrada Girona, G. Paci, E.A. Lemke, P. Kele
Chem Commun (Camb) 2017, 53(50), 6696-6699
Bioorthogonal double-fluorogenic siliconrhodamine probes for intracellular super-resolution microscopy
Link to the article

V. Sakin, J. Hanne, J. Dunder, M. Anders-Össwein, V. Laketa, I. Nikic, H.G. Kräusslich, E.A. Lemke, B. Müller
Cell Chem Biol. 2017, 24(5), 635-645
A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility
Link to the article

S. Flade, J. Jasper, M. Gieß, M. Juhasz, A. Dankers, G. Kubik, O. Koch, E. Weinhold, D. Summerer
ACS Chem. Biol. 2017, 12(7), 1719-1725
The N6-Position of Adenine Is a Blind Spot for TAL-Effectors That Enables Effective Binding of Methylated and Fluorophore-Labeled DNA.
Link to the article

X. Chen, M. Venkatachalapathy, D. Kamps, S. Weigel, R. Kumar, M. Orlich, R. Garrecht, M. Hirtz, C.M. Niemeyer, Y.W. Wu, L. Dehmelt
Angew. Chem. Int. Ed. 2017, 56(21), 5916-5920
"Molecular Activity painting": Switch-like, Light-Controlled Perturbations inside Living Cells (Hot paper, inside cover story)
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O.Demeter, A. Kormos, C. Koehler, G. Mezo, K. Németh, E. Kozma, L.B. Takács, E.A. Lemke, P. Kele
Bioconjug Chem. 2017, 28(5), 1552-1559
Bisazide Cyanine Dyes as Fluorogenic Probes for Bis-Cyclooctynylated Peptide Tags and as Fluorogenic Cross-Linkers of Cyclooctynylated Proteins.
Link to the article

C.G.F. Graf, C. Schulz, M. Schmälzlein, C. Heinlein, M. Mönnich, L. Perkams, M. Püttner, I. Boos, M. Hessefort, J.N. Lombana Sanchez, M. Weyand,  C. Unverzagt
Angew. Chem. Int. Ed.2017, 56(19), 5252-5257
Synthetic Glycoforms reveal Carbohydrate-Dependent Bioactivity of Human Saposin D
Link to the article

A. Pech, J. Achenbach, M. Jahnz, S. Schülzchen, F. Jarosch, F. Bordusa, S. Klussmann
Nucleic Acids Res.2017, 45(7), 3997-4005
A thermostable d-polymerase for mirror-image PCR
Link to the article

A.Yang, S. Pantoom, Y.W. Wu
Elife 2017, pii:e23905, DOI: 10.7554/eLife.23905
Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Link to the article

T. Anton, S. Bultmann
Nucleus 2017, 8(3), 279-286
Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas System
Link to the article

D. Schumacher, O. Lemke, J. Helma, L. Gerszonowicz, V. Waller, T. Stoschek, P.M. Durkin, N. Budisa, H. Leonhardt, B.G. Keler, C.P.R. Hackenberger
Chem. Sci. 2017, 8, 3471-3478
Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling
Link to the article

A. Stengl, D. Hörl, H. Leonhardt, J. Helma
SLAS Discovery 2017, 22(3), 309-315
A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies
Link to the article

J.E.G.A. Dold, J. Pfotzer, A.-K. Späte, V. Wittmann
ChemBioChem 2017, 18(13), 1242-1250
Dienophile-Modified Mannosamine Derivatives for Metabolic Labeling of Sialic Acids: A Comparative Study
Link to the article

L. Schmohl, J. Bierlmeier, F. Gerth, C. Freund, D. Schwarzer
J Pept Sci.2017, 23, 631-635
Engineering sortase A by screening a second-generation library using phage display
Link to the article

M.C. Lechler, E.D. Crawford, N. Groh, K. Widmaier, R. Jung, J. Kirstein, J.C. Ttrinidad. A.L. Burlingame. D.C. David
Cell Rep. 2017, 18(2), 454-467
Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
Link to the article

R. Röder, J. Helma, T. Preiß, J.O. Rädler, H. Leonhardt, E. Wagner
Pharm. Res. 2017, 34, 161-174
Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells
Link to the article

M. Braner, R. Wieneke, R. Tampé
Chem.Commun. 2017, 53, 545-548
Nanomolar affinity protein trans-splicing monitored in real-time by fluorophore-quencher pairs.
Link to the article

A. Wieczorek, P. Werther, J. Euchner, R. Wombacher
Chem.Sci. 2017, 8, 1506-1510
Green- to far-red-emitting fluorogenic tetrazine probes - synthetic access and no-wash protein imaging inside living cells.
Link to the article

S. Hauke, A. von Appen, T. Quidwar, J. Ries, R. Wombacher
Chem.Sci. 2017, 8(1), 559-566
Specific protein labeling with caged fluorophores for dual-color imaging and super-resolution microscopy in living cells.
Link to the article

S. Palei, H.D. Mootz
Methods Mol. Biol. 2017, 1495, 77-92
Preparation of semisynthetic peptide macrocycles using split inteins.
Link to the article

S. Mayer, K. Lang
Synthesis 2017, 49, 830
Tetrazines in Inverse-Electron-Demand Diels-Alder Cycloadditions and Their Use in Biology
Link to the article

V. Siegmund. B. Piater, B. Zakeri, T. Eichhorn, F. Fischer, C. Deutsch, S. Becker, L. Toleikis, B. Hock, U. Betz, H. Kolmar
Sci. rep. 2016, 6, 39291
Spontaneous Isopeptide Bond Formation as a Powerful Tool for Engineering Site-Specific Antibody-Drug Conjugates
Link to the article

I. Nikic, G.E. Girona, J.H. Kang, G. Paci, S. Mikhaleva, C. Koehler, N. V. Shymanska, C.V. Santos, D. Spitz, E.A. Lemke
Angew. Chem. Int. Ed. 2016, 55(52), 16172-16176
Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy
Link to the article

S. Voss, D.M. Krüger, O. Koch. Y.W. Wu
Proc. Natl. Acad. Sci USA 2016, 113(50), 14348-14343
Spatiotemporal imaging of small GTPases activity in live cells.
Link to the article

S. Maurer, M. Giess, O. Koch, D. Summerer
ACS Chem. Biol. 2016, 11, 3294-3299.
Interrogating key positions of size-reduced TALE-repeats reveals a programmable sensor of 5-carboxlcytosine
Link to the article

Y.J. Lee, M.J. Schmidt, J.M. Tharp, A. Weber, J. Gao, M.L. Waters, D. Summerer, W.R. Liu
Chem. Commun. 2016, 52(85), 12606-12609.
Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader
Link to the article

J. Bertran-Vicente, M. Penkert, O. Nieto-Garcia, J.-M. Jeckelmann, P. Schmieder, E. Krause, C.P.R. Hackenberger
Nature Comm. 2016, 7, Article number: 12703
Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides.
Link to the article

L. Thoring, D.A. Wüstenhagen, M. Borowiak, M. Stech, A. Sonnabend, S. Kubick
PLoS ONE 2016, 11(9), e0163670
Cell-Free Systems Based on CHO Cell Lysates: Optimization Strategies, Synthesis of "Difficult-to-Express" Proteins and Future Perspectives.
Link to the article

R.B. Quast, B. Ballion, M. Stech, A. Sonnabend, B.R. Varga, D.A. Wüstenhagen, P. Kele, S.M. Schiller & S. Kubick
Sci. Rep. 2016, 6, 34048
Cell-Free synthesis of functional human epidermal growth factor receptor: Investigation of ligand-independent dimerization in Sf21 microsomal membranes using non-canonical amino acids.
Link to the article

A. Guesdon, F. Bazile, R.M. Buey, R. Mohan, S. Monier, R.R. Garcia, M. Angevin, C. Heichette, R. Wieneke, R. Tampé, L. Duchesne, A. Akhmanova, M.O. Steinmetz, D. Chrétien
Nature Cell Biology 2016, 8, 1102-1108
EB1 interacts with outwardly curved and straight regions of the microtubule lattice.
Link to the article

M. Mönnich, S. Eller, T. Karagiannis, L. Perkams, T. Luber, D. Ott, M. Niemietz, J. Hoffman, J. Walcher, L. Berger, M. Pischl, M. Weishaupt, C. Wirkner, R.G. Lichtenstein, C. Unverzagt
Angew. Chem. 2016, 128, 10643-10648
Angew. Chem. Int. Ed.2016, 55, 10487-10492
Highly Efficient Synthesis of Multiantennary Bisected N-glycans Based on Imidates
Link to the article

P. Rathi, S. Maurer, G. Kubik, D. Summerer
J. Am. Chem. Soc. 2016, 138, 9910-9918
Isolation of human genomic DNA sequences with expanded nucleobase selectivity
Link to the article

L. Zhao, C. Ehrt, O. Koch, Y.W. Wu
Angew. Chem. Int. Ed. 2016, 55(28), 8129-8133.
One-Pot N2C/C2C/N2N Ligation To Trap Weak Protein-Protein Interactions.
Link to the article

A.-K. Späte, J.E.G.A. Dold, E. Batroff, V.F. Schart, D.E. Wieland, O.R. Baudendistel, V. Wittmann
ChemBioChem 2016, 17, 1274-1383
Exploring the Potential of Norbornene-Modified Mannosamine Derivatives for Metabolic Glycoengineering.
Link to the article

G. Kubik, D. Summerer
ChemBioChem 2016, 17, 975-980
TALEored epigenetics: a DNA-binding scaffold for programmable epigenome editing and analysis
Link to the article

B. Simon, A.-S. Huart, K. Temmerman, J. Vahokoski, H.D.T. Mertens, D. Komadina, J.-E. Hoffmann, H. Yumerefendi, D. Svergun, P. Kursuli, C. Schultz, D. Hart, A. McCarthy, M. Wilmanns
Structure 2016, 24, 851-861.
Death-associated protein kinase activity is regulated by coupled calcium/calmodulin binding to two distinct sites.
Link to the article

R.B. Quast, A. Sonnabend, M. Stech. D.A. Wüstenhagen, S. Kubick
Sci. Rep. 2016, 6, 30399
High-yield cell-free synthesis of human EGFR by IRES-mediated protein translation in a continuous exchange cell-free reaction format.
Link to the article

S. Schwagerus, O. Reimann, C. Despres, C. Smet-Nocca, C.P.R. Hackenberger
J. Pept. Sci. 2016,22(5), 327-333
Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation
Link to the article

H.-Y. Chiu, W. Deng, H. Engelke, J. Helma, H. Leonhardt, T. Bein
Sci. Rep. 2016, 6, 25019
Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.
Link to the article

M. Best, I. Porth, S. Hauke, F. Braun, D.P. Herten, R. Wombacher
Org. Biomol. Chem 2016, 14(24), 5606-5611
Protein-specific localization of a rhodamine-based calcium-sensor in living cells.
Link to the article

C. Koehler, P. Sauter, M. Wawryszyn, G. Estrada Girona, K. Gupta, J.J.M. Landry, M.H. Fritz, K. Radic, J.-E. Hoffmann, Z. Angel Chen, J. Zou, P. Siong Tan, B. Galik, S. Junttila, P. Stolt-Bergner, G. Pruneri, A. Gyenesei, C. Schultz, M. Bosse Biskup, H. Besir, V. Benes, J. Rappsilber, M. Jechlinger, J.O. Korbel, I Berger, S. Braese, E.A. Lemke
Nat. Methods 2016, 13, 997-1000
Genetic code expansion for multiprotein complex engineering
Link to the article

D. Schumacher, C.P.R. Hackenberger, H. Leonhardt, J. Helma
J. Clin. Immunol. 2016, 36, 100-107 (Review)
Current Status: Site-Specific Antobody Drug Conjugates.
Link to the article

B. Valldorf, H. Fittler, L. Deweid, A. Ebenig, S. Dickgiesser, C. Sellmann, J. Becker, S. Zielonka, M. Empting, O. Avrutina, H. Kolmar
Angew. Chem. Int. Ed. 2016, DOI: 10.1002/anie.201511894
An Apoptosis-Inducing Peptidic Heptad That Efficiently Clusters Death Receptor 5.
Link to the article

S. Palei, H. Mootz
ChemBioChem. 2016, 17(5), 378-382
Cyclic Peptides Made by Linking Synthetic and Genetically Encoded Fragments
Link to the article

X. Chen Y.W. Wu
Org. Biomol. Chem. 2016, 14(24), 5417-5439.
Selective chemical labeling of proteins.
Link to the article

F. Doll, A. Buntz, A.-K. Späte, V.F. Schart, A. Timper, W. Schrimpf, C.R. Hauck, A. Zumbusch, V. Wittmann
Angew. Chem. Int. Ed. 2016, 55, 2262-2266
Visualization of Protein-Specific Glycosylation inside Living Cells.
Link to the article

W. Fischle, D. Schwarzer
ACS Chemical Biology 2016, 11(3), 689-705 (Review)
Probing Chromatin-modifying enzymes with Chemical Tools.
Link to the article

A. Kollmannsperger, A. Sharei, A. Raulf, M. Heilemann, R. Langer, K.F. Jensen, R. Wieneke, R. Tampé
Nature Commun. 2016, 7, Article number 10372
Live-cell protein labelling with nanometre precision by cell squeezing
Link to the article

C. Meyer, S. Liebscher, F. Bordusa
Bioconjugate Chem2016, 27(1), 47-53
Selective Coupling of Click Anchors to Proteins via Trypsiligase
Link to the article

A. Stützer, S. Liokatis, A. Kiesel, D. Schwarzer, R. Sprangers, J. Söding, P. Selenko, W. Fischle
Molecular Cell 2016, 61, 247-259
Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails.
Link to the article

J. Seidel, C. Klockenbusch, D. Schwarzer
Chembiochem 2016, 17(5), 398-402
Investigating deformylase and deacylase activity of mammalian and bacterial sirtuins.
Link to the article

A. Dose, J. Sindlinger, J. Bierlmeier, A. Bakirbas, K. Schulze-Osthoff, S. Einsele-Scholz, M. Hartl, F. Essmann, I. Finkemeier, D. Schwarzer
Angew. Chem. Int. Ed. 2016, 55, 1192-1195
Interrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical Probes.
Link to the article

E. Hoffmann, K. Streichert, N. Nischan, C. Seitz, T. Brunner, S. Schwagerus, C.P.R. Hackenberger, M. Rubini
Molecular BioSystems 2016, DOI: 10.1039/C5MB00857C
Stabilization of bacterially expressed erytropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylaton sites.

M. Braner, A. Kollmannsperger, R. Wieneke, R. Tampé
Chem.Sci. 2016, 7, 2646-2652
'Traceless' tracing of proteins - high-affinity transsplicing directed by a minimal interaction pair.
Link to the article

V. Herbring, A. Bäucker, S. Trowitzsch, R. Tampé
Sci Rep 2016, 6, 36907
A dual inhibition mechanism of the herpesviral ICP47 arresting a conformationally thermostable TAP complex
Link to the article