Projects

In the 2nd funding period, the following projects are funded by the DFG:

Annette Beck-Sickinger, Oliver Seitz
Selective bioconjugation of proteins in live cells via peptide-directed acyl and alkyl transfer reactions

Frank Bordusa
Semisynthesis of antibody drug conjugates via biocatalysis

Sebastian Bultmann, Kathrin Lang
Genetic Code Expansion for Protein-Protein and Protein-DNA Interaction Studies in Dynamic Cellular Systems

Maria Cristina Cardoso, Christian Hackenberger, Heinrich Leonhardt
Site-specific functionalization of nanobodies: From labeling to cellular uptake

Ulf Diederichsen, Harald Kolmar
Selective multifunctionalization of antibody fragments and antibodies by enzyme-mediated orthogonal ligations

Thomas Dierks, Kristian Müller, Norbert Sewald
Twofold bio-orthogonal derivatization of antibody fragments by two different C(alpha)-formylglycine generating enzymes for generation of antibody-drug conjugates

Christian Freund, Dirk Schwarzer
Establishing strategies for sortase-catalyzed multi-peptide assemblies to profile T-cell selectivity

Christian Hackenberger, Janine Kirstein
Chemoselective Staudinger-induced Michael-additions to antibodies to analyze protein homeostasis in C. elegans

Aymelt Itzen
Application of an enzymatic protein labeling strategy based on CDP-choline analogues

Edward A. Lemke, Carsten Schultz
Specific labeling of proteins within living cells with single residue precision through genetically encoded click chemistry

Andreas Marx
Targeted poly(ADP-ribosyl)ation of proteins

Henning Mootz
New approaches for the site-selective chemical modification of therapeutic proteins under mild conditions

Daniel Summerer
Programmable and Chemoselective Protein-DNA Crosslinking for Sensitive Detection of 5-Formylcytosine

Robert Tampé
Cellular Logistics - 'Traceless' protein modification by small high-affinity tags

Carlo Unverzagt
Semisynthesis of natural glycoforms of human erythropoietin

Valentin Wittmann
Exploiting Diels-Alder Reactions with Inverse Electron Demand for Bioorthogonal Labeling of Alkene-Substituted Fucosylated Glycoproteins in Cells

Richard Wombacher
Protein labeling in living cells - A combination of enzyme mediated peptide labeling and inverse electron demand Diels-Alder cycloaddition

Yaowen Wu
Mechanistic studies of Legionella effector RavZ function in host autophagy using semi-synthetic LC3 proteins